It depends if Superman can hit Goku with his Super Flare ability.
If Goku realizes the danger, he may be able to IT out of there, but given he struggled to do it when Kid Buu blew up the Earth, he may have trouble going far away to avoid an explosion that can wipe out half a Galaxy.
If Goku thinks he can handle the blast, hes done.
Other then that, I don't know enough about ONLY new Superman 52. The Super FLare is the deciding factor in this battle. If it hits, Superman wins. If not, he loses.
But if you want to get technical, running away may give the victory to Superman by leaving the location of the fight.
Depends on how you look at running away.