Hashirama, SM and the sharingan are more or less equal in pre-cog depending on the users so that cancels out but the difference is that Hashirama hits harder, a lot harder due to SM so he takes it.
Hashirama has greater strength, more stamina, and can heal his wound. Sage Mode = Sharingan in terms of boosting the shinobi's reflexes. Hashirama wins.