If I could make my own moveset and be at least Tobirama if not Hashirama/Madara level, I'd pick Senju. If I could get EMS as an Uchiha it would be tempting, but the only Mangekyo that impresses me truly is Kamui. If I could completely design the EMS STJ I'd be tied with Uchiha.
I like health & stamina tanks that take forever to kill or wear down.