There's always possibilities of newer developments. Naruto as a series for kids has already ended. If it does continue in some form, it will probably be targeted at fans of the original series (thus teens and young adults), meaning things like extramarital *** will actually be a thing (implied, but not shown).
Going by that logic, what's keeping Sasuke from making a powerful baby with Uzumaki Karin on one of his 'research adventures'. We all know how 'research' translates in Naruto.
So, by the time Sarada is 15 or so, we may even find out that she's not the sole Uchiha, and that Sasuke may have accidentally betrayed on Sakura at some point. Sasuke may try to save their marriage by means of Genjutsu on Sakura, or by killing the kid with fire.
The latter path could also lead the way to a new villain, stronger than ever because of mixed Uzumaki/Uchiha genes, with Sarada's eyes for an EMS, added with Orichimaru/Kabuto's experiments could lead to a powerful foe strong enough to keep Naruto or Sasuke busy individually.
EDIT: Yes, this is fanfic because this whole thread is.
/FANFIC