Sakura is by and far away one of the finest characters in the entire manga. Why? Because she symbolises female doctors perfectly. For one, the stress of such a strenuous profession clearly takes a gargantuan toll on her, as evidenced by her wild bi-polar like mood swings that make an "ordinary" PMSing girl look like a calm 7-year-old girl. She also symbolises the fact that doctors have tough personal lives, as evidenced by her relationship with her husband.
There is only one flaw you could pick out if you're picky- why was Sakura at home at the end if this is what Kishi wanted to portray? It's simple-a la the Occam's Razor principle. Kishi "forgot" to show her working massive hours and punching her colleagues at work. Kishi is clearly a writer whose writing skill is on par with the likes of Jane Austin, Ernest Hemingway, Charles Dickons etc. So yeah, the stress of his work made him forget, which is what he actually meant in that interview about Sakura. In other words, Sakura is a great character if we look at what Kishimoto meant to symbolise her as-a perfect female doctor. Carry on.
