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All it would take is one vacuum wall palm to kill sakura :-( , the wide spread jyuken chakra would consume her tiny body as it did the juubi's tail consumin her seal along with everthing lol , its basically a full body jyuken attack an we already seen wat a tiny touch of it did to a a healthy cm2 kidomaru not to mention the shockwave=-O , sakura and tsunade stand no chance without the epic slug plugB-)
Vacuum wall palm required both Neji and Hinata. Lol Though Hiashi could do it by himself.
That kind of negates your argument, though Hiashi could potentially beat Sakura and Tsunade.
I still think that Byakugou could regenerate the damage, Tsunade did put her lower and upper half together. Yes, Karin did help but that was only because Tsunade spent a lot of her chakra keeping herself and the Gokage alive as well as summoning Katsuya.
But, we can only speculate the capabilities of Byakugou Regeneration, so it's difficult to argue the point.