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A. The fourth databook confirmed her as a user. And we have already seen it on her forehead. She obviously predates Tsunade and her usage. Now we don't no for sure if she created the technique but she is the oldest known user and regardless Tsunade did not create it.
B. We have no idea when she started using it. And the seal can be invisible if needed as Sakura has shown while she gathered chakra the past three years. So even in flashbacks of her without it you can't say she didn't use it. Practically though I would expect that she only started using it after becoming a medical ninja in her late teens or early adulthood as it aids her in that area. Sakura using it earlier does not make her superior at all as she needed it earlier.
We know for fact that she didn't have it during her youth or during the war of her era..
Tsunade before her brother death
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Tsunade healing Dan with medical ninjutsu
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Also, Sakura s seal was never invisible it wasn't devolped.. And she had to learn it in order to master Tsunade techniqus, if u noticed many of their jutsu relies on the seal..