Hiruzen loses both scenarios. People should stop posting his Edo Tensai feats. They are not credible here. When he died, he could barely make two clones and all the Anbu standing outside the barrier were calling him a fool along with Orochimaru:
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His Doton and Katon attacks were borderline pitiful, something easily countered by Tobirama's little suiton and his poor Doton mudslide barely managed to block it:
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He could even hit to mindless Edos, who handed his ass to him in CQC:
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He neither has the chakra, nor the stamina to make create techniques that span that size. Nor is he making 4 Kage Bushins, when 2 nearly killed him. Sasori has the speed and the numbers to take him out. All he has to do is bring out the Third kazekage and use world model. It's over for him then. He is neither dodging it, nor is Enma doing much here, given that as soon as it was restrained, it was down, for good and the staff reverted back to its original form:
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Which means if the staff is hit, pinned, Enma is done. Hiruzen could not even overpower Orochimaru, despite Enma intervening to take a swipe at Orochaimru:
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It is pretty easy for Sasori to avoid enma, as he can simply switch puppet bodies. He is not moving to avoid Iron Sand pellet for which Chiyo had to use a chakra barrier. He isn't evading about a hundred puppets for which Chiyo had to summon her own to fight against. He is defeated easily in both scenarios.
An Antidote won't help him given that it only works for three minutes and there is not a weapon in Sasori's arsenal that isn't poisoned. Even Iron Sand is. S1 Sasori wins low difference, S2 he takes it mid difference may be, and I am being generous here.