Tsunade can push IC Itachi to mid difficulty.
it's med diff. He still has to go through 5% katsuyu which will be a pain for someone with his chakra reserves.
Only MS Itachi stands a chance and considering his reserves he might even lose.
Does Darui beat Tsunade? Irrelevant to the thread, but I think I saw you saying it before.(just curious as to why you think so?