If Hidan aims for the heart or brain, I think he could kill Sakura. Of course, whether stabbing the heart and brain would actually kill sakurs is totally irrelevant, since she can rid Hidan of the curse mark by punching the ground. Hidan also likes to take his time fighting opponents, so he more likely than not will not one shit Sakura. Asuma was unable to stop Hidan because he was too bust screaming in pain like a little baby. This wouldn'tt be a problem for sakurs since she could endure that pain and charge at Hidan.