Kimi will eventually exhaust Chakra fighting the 3.Suprise attack from Karin's Chains or Jugo's Boosters.Suigetsu's Hydrification.
Karin has her amazing Stamina making Her hard to beat Jugo can be tough but not him suigetsu and karin will exhaust his chakra and hell die if his disease.Then Karin Heals herself at the end.
Not really. Its not like he'll have to make a big effort to get rid of Juugo and Karin, the only problem is Suigetsu because of his weird body (which has limits, Kishi simply didn't established more boundaries other than Raiton).
Karin is simply not a fighter. If someone like Guruguru (who's not even a taijutsu specialist to begin with) managed to swiftly close his distance and injure her w/o retaliation, Kimi will certainly do the same but with more ease. She's got two bites before being out of comission, which she'll either waste on herself or her teammates. That's nothing considering the opponents they're facing.
Juugo was constantly stopped by Kimimaro whenever he went psycho, and by the way Jugo spoked i don't think it was with much struggle. He said only Kimi could stop him, pretty much putting him above anyone else working for Oro.
Anyway, this isn't Kimi vs Juugo, Suigetsu and Karin. The only member i can see surviving against Kimi is Suigetsu, but he can't do anything against Guren so... Team vessel eventually wins.