Try again, The seal can also be applied during combat, and can secretly be placed on the opponent's body. When the user activates it, the curse seal's marks spread around the opponent's body, paralysing them. However, one can break free from the seal with a strong enough release of chakra.
Tsunade mid diff.
Tsunade beats most Uchiha's she basically hashirama without mokuton
And the eye thingy is still genjutsu, which requires one to control their opponents chakra in their brain, Tsunade's seal released should negate the effects