Goku is an 18 year old White American.
Goku shares NO similarities to the manga/anime Goku.
Bulma's hair is not blue.
Piccolo has a random female side-kick.
Goku didn't have a tail.
Goku transforming didn't have any explanation.
Master Roshi isn't even old.
The Kamehameha does NOT work like how it looks like in the Anime/Manga.
No Krillin.
Goku is too weak.
Goku is civilised.
Goku goes to school.
Goku has a crush on girls.
Goku wears leather jackets.
No nimbus.
Goku uses sarcasm.
According to Goku, Grandpa Gohan says to "beware the Nameks". In the manga, no one knew what a Namekian was (or that King Piccolo, Kami, or Piccolo Jr. were Nameks) until the Saiyan saga.
Goku uses the Dragonballs to revive Master Roshi instead of Grandpa Gohan.
Power pole is just a normal bo.
Kamehameha heals people.
In the film, he is shot by Piccolo's sidekick with her gun and almost dies. In the manga, Goku was shot by Bulma in the head with a regular handgun and was barely even affected by it.
Goku was able to sense Roshi's ki without having to drink the Ultra Divine Water.
Those are what I can think of now...