Yes it dose Sasuke and Naruto are both related to Kaguya by Bloodline Sakura is not. Get used to it.It has nothing to do with bloodline, or mediate between two people, or who's the opposite.
From Mist "Reincarnations are related to peoples ideology and values. Kaguya was a brutal power hungry thug who wanted to rule by power." Which doesn't describe anybody else other than Madara