I'm under the impression Hebi Sasuke is immune to Sasori's poison.
1. Orochimaru made Sasuke immune to different poisons.
2. Orochimaru worked side by side with Sasori in Akatsuki at one point.
Either way i'm confident in Sasuke's taijutsu/speed that he can dodge w/e Sasori dishes out.
Sasori will be pushed (or killed in) out of Hiruko.
Sharingan allows him to see that the chakra heart piece is what allows Sasori to live. A simple chidori true spear takes care of that.
Sasuke has the speed feats to dodge iron sand, lightning should have the advantage because the sand is made of iron, but i'll bring up the fact that Sasori has no defense to stop Chidori true spear.
Let's say Sasori is forced in to using 100 puppets. Aoba/Manda will steamroll all of them.
Verdict: Hebi Sasuke mid-high difficulty.