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I suppose everyone is born with different potency/quality of chakra. It might imply different things depending on how the ninja further develops, just like with physical or mental abilities of a real person.
Lets take Kushina for example, she has a strong life force meaning her chakra is strong (having a lot of influence) but she doesn't have a lot of it , so Madara is the same case.... its like Madara is a hybreed of Uchiha that has Senju strong life force.