Against a "Perfect" Susanoo Kakuzu, Deidara, Sasori and Hidan are all non-factors. They are incapable of doing anything to a PS, Sasuke will be able to easily look past them. For the most part this is a sick Itachi and Kisame up against Sasuke. Itachi's best bet at protection will be his Yata Mirror, but he won't be able to hold up Susanoo indefinitely. With knowledge Sasuke will know to take out Kisame first. After Kisame is gone all threats to Sasuke will have been completely quelled.
Sasuke wins, mid difficulty.
Without knowledge Sasuke won't know who to take out first which might have the potential to muddy the result a bit. Sasuke wins with high difficulty in that scenario.