The onlything I can see in Sasukes arsenal that would actually be able to kill Kimi would be Kirin. So my answer is as long as Sasuke hasn't had an extended prep time to set up a Kirin Kimimaro takes this...
Genjutsu followed by a kunai to his eye. GG
We both know that's not how it works.
It works just like this. Kimimaro has no genjutsu feats. Even the databook gives him only 3 points, Sasuke has 4.