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How so? Can you clarify or support your hypothesis?
simple, we saw and know for a fact, that mangekyo sharingan blinds the user eventually, it takes away light, and in the final battle with sasuke, itachi barely see not only that. It puts a strain in the user and the eyes, and in medical stuff your eyes is connected to the brain with that overuse of susanoo and totsuka it could put a huge massive strain on Itachi's brain.
susanoo is also said to consume the castor.
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here it read
A godlike technique used only by those who have achieved mastery beyond the mangekyo sharingan,
a jutsu feared by those around them as the most powerful of the ocular jutsu. it is the castor's guardian deity. And at the same time CAN CONSUME THE CASTOR AS WELL
Now you might say oh well madara used susanoo, it dont consume him aaah! :I Madara has EMS, it dont affect him, then you might say well sasuke!! sasuke's ms strain did not went beyond like Itachi's own, Sasuke's quickly got EMS,
so really in fact, its not aids nor hiv or cancer LUL its Itachi's own eyes that killed him. His own powers consumed him