lol Bee is below Itachi, how can he be above the Uchiha bros?
I will use Real Itachi and not the Edo because they were being controlled by Kabuto while fighting Naruto and Bee:
You must be registered for see links
In this scenario it all comes down, not to raw power and speed but reaction time. Itachi usually starts his fights with Tsukyomi which has worked on Bee before and for the few seconds he is "unconscious" He could easily be killed by Sharingan techniques in a given distance.
Also Totsuka being a variant of Kusanagi definitely doesn't imply that it maintains the same Limits and abilities. For starters, Kusanagi is a Physical sword while totsuka is an ethereal Sword.
To conclude, Bee wouldn't be getting to TBV2 if faced with such a team.