Kishi may had given the hints.
Naruto = Jiraiya. Sasuke = Orochimaru. Sakura = Tsunade (both medic nin).
Jiraiya had always protected Tsunade. Tsunade lost the Ones she loved. Also Jiraiya always went after Orochimaru knowing the latter objective.
Naruto had always protected Sakura, knowing her liking. Also Naruto always after Sasuke. Team 7 had build a very strong close relationship among them. Itachi always told Sasuke to kill the most loved person in order to be strong. Sasuke could easily killed Naruto twice, but did not. Sasuke could also easily kill Sakura, but did not, understanding Sakura mind. This show that what his brother told him how, but Sasuke had probably had his own motto and need not to kill.
When Jiraiya wanted to go and see Nagato, Tsunade knowing him, could not able to stop him going. When news that Jiraiya was dead, Tsunade became sad. Tsunade also did punched Jiraiya, just like Sakura beat Naruto.
Sasuke=Obito (Uchiha), Sakura=Rin (both medic nin), Naruto=Kakashi. Obito told Kakashi to protect Rin
Conclusion: Both Sannin & Team 7 had created strong relationship. Not forgetting Kakashi, Obito & Rin; similarity. Now Tsunade (Rin) will die.
Like Orochimaru, Sasuke are also want to destroy Konoha. None of them were married!!!!...................................