Zetsu is made by Black + White. They can fight at the same time. Black Zetsu is far more than enough to solo Tsunade, anyway.
Zetsu is so incredibly underrated. People don't even know his abilities probably, or since he doesn't have big AoE attacks these abilities are deemed as nothing impressive. Typical shitty DBZ logic, but that doesn't work with Naruto: Deidara can destroy a village with ease, Itachi or Kakashi (if not DMS version) cannot, still they can fodderize Deidara with their hax and skills. Part 1 Temari showed more destructive feats than Hidan, I guess she's more powerful than him? I don't think.
People have the misconception that Zetsu isn't a good fighter, but that's only true for White Zetsu, not for the other half Black Zetsu. It's clearly made a difference (
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). Also not being able to take on Pain Arc SM Naruto and Pain Arc Kakashi it's not that detrimental, I'd say, for Zetsu, but we know that White Zetsu is more a support, with his clones and supplementary skills, for Black Zetsu who is the fighter, and still fights with guerrilla tactics and not directly.
KCM Naruto's Kage Bunshin is able to outperform the 3rd Raikage and land Rasenshuriken on him even without any external help (
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). An equally powerful Kage Bunshin even with the help of the Mizukage, Genma, Raido and some other strong jonin and chunin level ninja (so not top tiers but at least decent level shinobi) is unable to defeat Black Zetsu and to hit him with Rasenshuriken (
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). The fact that Black Zetsu was "defeated" by Chojuro is not detrimental to him, as Zetsu was playing around and didn't expect Chojuro's sword to have that unpredictable effect (even all the other people around were surprised. A focused Black Zetsu is able to react to KCM Naruto (with his no full Shunshin speed, yeah, that is not as good as his full Shunshin speed but still on par with Itachi (
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), Obito (
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) and V1 Raikage (
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), not bad I'd say) and to Kakashi (who is able to blitz Zabuza, to outspeed Obito (
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)(
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) and to keep up with Gated Gai (
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) even counterblitzing Sharingan and Rinnegan enhanced V2 landing Raikiri on them (
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) and also is hyped for his speed (
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)) together with Minato (
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), even evading quick attacks from Minato faster than he can even finish them (
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). Someone able to react to said speedsters would laugh at Choujuro if serious and focused on him, logically. Not to mention that Black Zetsu was perfectly alive and kicking after Chojuro's trick anyway.
It's true that Black Zetsu admitted that he would die in seconds against Kakashi and Minato (
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). Well then, out that god tiers and top tiers, how many S-rank/kage level shinobi won't die in seconds against Kakashi with Kamui and Minato with Hiraishin? So I don't see that statement as detrimental at all. Zetsu is not that powerful if he fights the opponent directly, but if he uses guerrilla tactics, which are what his skillset allows him, he is very tough.
With great reflexes, as showed, such to react to great speedsters with relative ease, he also has sensory abilities (
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), and can move at great speed thanks to his Kagero, also someway melting with the surroundings (
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)(
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)(
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), and once he does that only a Rinnegan user can see him (it's not like everyone has a Rinnegan), and he can do that even splitting his body to be completely unnoticed (
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). With these skills, he can evade the majority of attacks, even fast or wide AoE ones, and he also can take most people by surprise: to his speed and mobility he can supplement his clones with Kisei Bunshin (White Zetsu's clones: they aren't powerful but can be very useful, for example they were able to set Zetsu's spores at the Gokage meeting with the Gokage unable to tell that (
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); defeating the clones can bring out Hoshi no jutsu, Zetsu's spores, that can bloom on people remaining unnoticed and then suck out people's chakra).
Black Zetsu is really hard to kill, he is basically like a black jelly in his true form, we witnessed how cutting his body in half does literally nothing to him (
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). He can take advantage of this to outlast his enemies or to take them by surprise: the combo of his mobility skills, supplementary skills and how hard is to kill him make him a tough opponent for most of S-rank/kage level shinobi. Most of people can't hit him, and even if they hit him, they won't kill him. While he can outlast them or take them by surprise, and suck dry their chakra or simply jump on the opponent and stick on him possessing and making them kill themselves; most of people don't have Obito's willpower to avoid Zetsu controlling them, even dying Obito's willpower is far above the one of people like Mei Terumi for example. Let's also not forget how Zetsu has great knowledge of nearly every opponent he can face thanks to the info he gathered. Zetsu can also use Mokuton.
To kill Zetsu you need to be able to actually hit him (which is very difficult due to his great movement speed and mobility with Kagero and with his reflexes and sensory skills) in first place and to make enough damage to erase him or have hax to defeat him (cutting him in half for example does nothing to him): you need attacks like Bijuu Dama to destroy him or hax like Kamui to take him out, but most people don't have things like that. Most people aren't actually able to put down Zetsu and to avoid him possessing them or sucking their chakra. I don't really see how Mu, 3rd Raikage, 2nd Mizukage, MS Sasuke, SM Naruto, Onoki, Jiraiya, Kakuzu, Hebi Sasuke, Deidara, Sasori, Shippuden and War Gaara, Fuuton training Naruto, Part 1 Kakashi, Old Hiruzen, Hidan, Konan, Darui, Tsunade, Mei Terumi, Mifune and below are actually defeating Zetsu for good.
Actually I don't see how Itachi is defeating Zetsu 10 times on 10. Zetsu is definitely able to react to his speed, if he could react to faster characters than Itachi. Zetsu can laugh about Itachi's base skills, since kunai, Suiton or Katon aren't doing shit to him, and he can dodge them anyway, but anyway he isn't taking any damage. He can fight as a jelly avoiding eye contact and so Sharingan genjutsu. He can move dodging Susanoo, Totsuka sword and Amaterasu, and even if it Susanoo can cut him in half and still do nothing, Amaterasu can kill him and he will just take out the part and be fine, only Totsuka will defeat him by sealing, but is it actually hitting him? I don't believe by feats. If Itachi doesn't manage to make a strategy to hit him with Totsuka or Tsukuyomi he can lose by being outlasted or by having his chakra drained, especially as he nearly faints everytime he uses Mangekyo, as seen in his fight with Sasuke, and even in part 1 he showed signs of great fatigue.
Minato too won't have an easy time. We already witnessed that Zetsu is able to react to his speed, Minato can manage to hit him with Hiraishin by setting marks and using his marked kunai, but a Rasengan or a kunai slash will do shit to Zetsu. Minato will win only with Shisho Fuuin.
I can see only God Tiers, Top Tiers, and people like MS/MS + Rinnegan Obito (Kamui), War Arc 1MS Kakashi (Kamui), Nagato (Chibaku Tensei), BM/BSM Naruto (Bijuu Dama, Cho Odama Rasenshuriken), 7th Gate Gai (blitz + Hiru Tora + Asa Kujaku) and so on winning against Zetsu 10 times on 10. He defeats most of the S-rank and kage level shinobi.