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Re-read my post. I said how do you think the ENTIRE clan has it? They obviously practice incest relations otherwise it'd only be in a few Hyuuga. Hashirama and Mito being somewhat related isn't a problem for this setting.
Dude my point is still valid to your question, incest isn't the answer if they had not being descendants of Hamura if they weren't they'd just be normal people with kids who are handicaped or w.e u call it.

, dominance goes for generations.