I'd think they were different. Therefore unique and someone I would love to get to know better.
I would treat them as I would any other person- with kindness, respect, and pure honesty. They would be, in a way, like Naruto. It's not his fault for the Juubi to be sealed inside him. But because of it, he was alone. As well as Gaara. All they need is someone to notice them.
I would attempt to become friends with them. I want them to feel wanted. It's not their fault if something like this were to happen.