bee gets stomped low difficultly.. Oro or Jiraiya could potentially do it themselves both together they low difficulty.. adding tsunade's strength and healing is just mean.
Sannin wins both scenarios low-med diff, Bees attacks won't go through Rashomons, Jiraiya can still use summons to stalemate him. Tsunade uses Katsuyu and then uses acid. Oro summons his hydra, Jiraiya uses Gamayu Endan and melts him.
How so in s2? Base Jiraiya and Orochimaru can't breach V2 cloak. Tsunade's punches are the only thing that can damage him, but he can exchange hits with her and tank one or two, but rip her apart in CQC.