Tsunade solos.
Orochimaru solos.
No for Tsunade
OT: You did not restrict edos. Orochimaru solos.
Oro gonna use Tsunade and Jiraiya as his sacrifices or something?
I'm obviously assuming he's already done the pre prepared sacrifices, no different to assuming someone has already signed the blood contract necessary for a summoning animal prior to the fight. Or at least, that's what I've seen others assume during my time posting here.(unless Edo tensei is outright restricted by the OP).
@boldWell that's not exactly the same thing. You need living sacrifices for Edo Tensei..you sign a summoning contract once and it's there for good/whenever you need it, but yes, it being prepared before hand is a possibility, but OP doesn't give us any info on how many he prepared(He's only shown that he has access to Hashirama, Tobirama, Hiruzen and Minato's DNA, so it's gotta be anywhere from 1 to 4), so I'm left assuming there's no ET use here.(again, unless he captures and then uses Jiraiya and Tsunade)
And yes, most people on this forum seem to assume ET can just be used out of random with any living being to sacrifice, and most OPs that expect ET to be a part of the fight don't even bother mentioning how many sacrifices there are. I dunno where they got that thought from, though.
The Sannin, mid-diff. Gai's attacks are all very powerful, but they are, for the most part, taijutsu. Orochimaru's bodily structure is the perfect counter to taijutsu, and a similar case could be made for Tsunade. Remember, Orochimaru was able to get sliced in half and, without showing any sign of being really seriously hurt if I recall correctly, reattached himself and kept fighting a moment later. Jiraiya doesn't have regeneration like the other two do, but we all know full well he's not useless in this fight.
That's assuming Edo Tensei is restricted. If Orochimaru can use his edos, he solo stomps.